Key Takeaways
- Letybo® is the newest FDA-approved neuromodulator in the U.S., backed by more than 31 million treatments performed globally before its domestic launch.
- Its protein-free formulation sets it apart from most competing neurotoxins, delivering precise, targeted results while reducing the risk of antibody resistance over time.
- Most patients begin seeing visible improvement within three to seven days, with full results developing around day 10 and lasting 12 to 16 weeks.
- Letybo® is worth considering for long-term Botox® users who’ve noticed diminishing results, as switching to a protein-free formula may help restore earlier levels of effectiveness.
- A typical session takes 10 to 15 minutes with no downtime, making Letybo® one of the most convenient options available for patients seeking natural-looking wrinkle reduction.
A Fresh Approach to Facial Rejuvenation
Synergy Face + Body by Travis Shaw, MD, now offers Letybo®, the newest FDA-approved neuromodulator for smoothing moderate to severe frown lines.
Letybo® is already popular in over 65 countries, including South Korea, where it goes by the name Botulax. With more than 31 million treatments administered globally, Letybo® arrives in the U.S. with a substantial international track record behind it. Now available at Synergy, it brings trusted results to clients in Richmond, Virginia, and Raleigh, North Carolina.
What Is Letybo®?
Letybo® is an injectable used to temporarily improve the appearance of moderate to severe glabellar lines, which are the vertical frown lines that appear between the eyebrows. These lines form due to repeated contractions of the muscles involved with frowning, concentrating, or squinting.
What sets Letybo® apart from many competing neuromodulators is its high-purity formulation. Unlike products that include accessory proteins alongside the active ingredient, Letybo® contains only the active neurotoxin itself. This refined manufacturing process is designed to deliver precise, consistent results while minimizing the risk of unwanted diffusion beyond the treatment area.
Quick Facts:
The Science Behind Letybo’s High-Purity Formula
Letybo® belongs to the same class of injectables as Botox® and Dysport®. Like those products, it works by blocking acetylcholine release at the neuromuscular junction, which prevents the targeted muscles from contracting and allows the overlying skin to smooth out.
Where Letybo® differs is in how it’s made. Its manufacturing process removes the complexing proteins found in most competing formulations. This protein-free approach, also used in Xeomin®, may lower the likelihood of the body developing antibody resistance over time. That’s a relevant consideration for long-term patients who’ve noticed their results becoming less consistent across repeated treatments.
Letybo®’s diffusion pattern also contributes to precise placement. Results tend to stay concentrated in the targeted area, which supports the natural, refined outcomes that patients are increasingly looking for.
Clinical data backs this up. In a pivotal Phase III trial involving 355 patients, 78.6% showed significant improvement based on investigator assessment at the four-week mark. A separate 2024 randomized controlled trial confirmed that Letybo® performs comparably to Botox® for treating moderate to severe glabellar lines, with no significant difference in safety outcomes between the two.
Letybo® vs. Botox® and Dysport®: What’s the Difference?
| Feature | Letybo® | Botox® | Dysport® |
|---|---|---|---|
| Onset of Results | 3–7 days | 3–5 days | 2–4 days |
| Duration | 3–4 months | 3–4 months | 3–4 months |
| Units Needed | Similar to Botox® | Baseline standard | Typically more units |
| Expression | Soft, natural look | Consistent smoothing | Strong for deep lines |
While all three neuromodulators are effective, Letybo® is an excellent option for patients looking for reliable, smooth results with a softer, more natural expression. Our providers can help you choose the best product based on your facial structure and goals.
Who Is a Good Candidate for Letybo®?
You’re likely a good candidate if you:
- Are over 18 and in generally good health
- Have dynamic wrinkles (caused by repeated muscle movement)
- Prefer a natural-looking, soft result that preserves expression
- Are new to neuromodulators or open to trying an alternative to Botox® or Dysport®
Letybo® can also be a strong option for patients who’ve used Botox® for several years and feel it’s becoming less effective. Because Letybo® uses a protein-free formulation, switching products may restore the consistent results patients experienced earlier in their treatment history.
However, Letybo® may not be recommended if you are pregnant, breastfeeding, have a known allergy to botulinum toxin, or have certain neuromuscular conditions. During your consultation, our team will carefully review your medical history and aesthetic goals to determine if Letybo® is the best fit for you.
Why Choose Letybo®?
- Natural-looking results: Letybo® delivers soft, smooth outcomes while preserving natural facial movement and expression.
- Fast-acting: Many patients notice improvement within a few days, making it ideal for those wanting quick, visible change.
- High precision: This formulation provides consistent, reliable results and meets rigorous standards for purity.
- Accessible pricing: Letybo® is typically priced competitively, often coming in below Botox® per treatment while delivering comparable clinical outcomes.
- Trusted global origins: Developed by Hugel, Inc. in South Korea, Letybo® reflects the exacting standards of one of the world’s most respected aesthetic medicine markets.
Treatment Process: What to Expect
A Letybo® session is simple and efficient. Here’s what the process looks like from start to finish:
- Consultation: Your provider reviews your medical history, assesses your facial anatomy, and discusses your goals. This step also confirms whether Letybo® is the right choice for your specific needs.
- Preparation: The treatment area is cleansed, and a topical numbing cream or ice can be applied for comfort if preferred.
- Injection: Using a fine needle, your provider delivers precise injections into the targeted muscle groups. Most sessions take between 10 and 15 minutes.
- Post-treatment: You can return to daily activities right away. For the first 24 hours, avoid strenuous exercise, alcohol, and any rubbing or direct pressure on the treated area.
Most patients begin seeing visible improvement within three to seven days. Full results develop around day 10, and results typically last 12 to 16 weeks with proper aftercare.
Post-Treatment Care for Optimal Results
The first 24 hours after treatment matter most. Avoid lying flat, bending forward for extended periods, or any activity that significantly elevates your heart rate or body temperature, as these can encourage the product to migrate from the treatment site.
Beyond the first day, consistent sun protection and a regular skincare routine support overall skin health and complement your results over time. Your provider will give you personalized aftercare instructions based on your treatment areas and goals.
As results begin to fade around the 12-to-16-week mark, scheduling a follow-up treatment helps sustain your improvement. With consistent sessions over time, some patients find that muscle activity gradually reduces, which can extend the window between treatments.
Your Letybo® Experience at Synergy
At Synergy Face + Body, we take the time to understand your goals. We start every treatment with a personalized full face assessment. During this consultation, we discuss your concerns and confirm whether Letybo® fits your needs.
If you’re new to neuromodulators or ready to try something different, our experienced injectors are here to guide you.
Book Your Consultation
Experience the fresh, refined results of Letybo®. Contact Synergy Face + Body to schedule your personalized consultation today.
Note: Results vary. Always consult with our trained injectors to find the best treatment plan for you.
