Botox, Dysport & Letybo: Compared 

What’s the Difference and Which Is Best?

If you’re considering a wrinkle reduction treatment, you’ve probably heard the names Botox, Dysport, and Letybo. They all target fine lines and expression wrinkles, but the way they perform can feel slightly different. 

What Do Botox, Dysport, and Letybo Have in Common?

All three are neuromodulators that soften facial lines by relaxing the muscles that create expression wrinkles. They’re commonly used for:

  • Frown lines (the “11s”)
  • Forehead lines
  • Crow’s feet
  • Bunny lines
  • Brow balancing
  • Jawline softening
  • Chin dimpling

They work similarly, but their formulation, onset time, spread, and dosing can influence your experience and results.

Side-by-Side Comparison

FeatureBotoxDysportLetybo
When wil I start seeing results?3-7 days 2-4 days 2-5 days
How long will it last?3-4 months3-4 months3-4 months
Spread of productMore localizedSlightly broaderSimilar to Botox
Best forPrecision, small areaLarger areas, softer spreadNatural movement, subtle, softening
Ideal forClassic control and precisionFaster onset, softer resultsSmooth, natural results

Botox: “The Gold Standard”

Botox is the most widely used and recognized neuromodulator. It’s known for:

  • High precision
  • Reliable dosing
  • Strong control in small areas

It’s often preferred for patients who want targeted smoothing without much spread into nearby muscles.

Dysport: Quick and Soft-Edged

Dysport is popular for people who want results a little faster and with a softer blend. Key perks include:

  • Onset in as little as 2–3 days
  • Slightly wider diffusion, ideal for broader areas
  • Great for strong muscles or more expressive foreheads

The units are measured differently, so the number may look higher but doesn’t mean a stronger dose.

Letybo: New, Refined, and Natural-Looking

Letybo is newer in the U.S. but well-established globally. Many injectors appreciate its balance of precision and softness. It offers:

  • Unit conversion that matches Botox
  • Subtle, natural-looking results
  • Smooth finish without stiffness

It’s an appealing option for patients who want an updated formula with minimal change in facial expression.


How to Choose the Right One

The best choice depends on your goals, anatomy, and how your body processes the product. Here’s a quick way to think about it:

  • Choose Botox for classic precision and long-standing reliability
  • Choose Dysport for quicker onset and a more blended effect
  • Choose Letybo for soft, modern, natural-looking movement

Our experienced injectors can guide you based on muscle strength, symmetry, expression patterns, and past treatments.

The Bottom Line

All three neuromodulators, Botox, Dysport, and Letybo, deliver excellent wrinkle-softening results. The differences come down to formulation, speed, spread, and aesthetic feel. A personalized consultation and full face assessment is the best way to determine your ideal match.